Class of 2007
| High School | Valedictorian |
| Advance High School | Alicia Reeves |
| Arcadia Valley High School | Edward M. King |
| Ballard Memorial High School | Stephanie Bodell |
| Ballard Memorial High School | John Austin Childress |
| Bell City High School | Racheal Long |
| Benton Consolidated High School | Casey Campbell |
| Benton Consolidated High School | Megan Cripps |
| Bernie High School | Kaycee Hughes |
| Bismarck High School | Lacey McCaulla |
| Bloomfield High School | Gavin McKain |
| Cairo High School | Angelica M. Johnson |
| Calloway County High School | Christina Millizer |
| Campbell High School | Jamie Noall |
| Cape Girardeau Central High School | Claire Segar |
| Carlisle County High School | Catherine Harris |
| Carterville High School | Sarah Sayavong |
| Central High School (Park Hills) | Brandon P. Mason |
| Century High School | Blake Thurston |
| Century High School | Brooke Regina Ulrich |
| Charleston High School | Daniel Barnes |
| Charleston High School | Jennifer Miller |
| Charleston High School | Catherine Presson |
| Clarkton High School | Larissa Gambling |
| Cobden High School | Rebecca Aldridge |
| Cooter High School | Robyn Michelle Frost |
| Cooter High School | Jenna Lynn |
| Crab Orchard High School | Mallory Anne McGuire |
| Delta C-7 High School | Lindsey Blankenship |
| Delta R-5 High School | AJ Horn |
| Dexter High School | Lydia Lancaster |
| Dongola High School | Hillary Dawn Hoffner |
| Doniphan High School | Melissa DeEtte Kennon |
| Du Quoin High School | Laura Childs |
| Du Quoin High School | Dillon Heape |
| Eagle Ridge Christian School | Kassy Hess |
| East Carter RII High School | Coral Pucce |
| East Prairie High School | Maggie Smith |
| East Prairie High School | Taylor White |
| Egyptian High School | Nathan Travis Jones |
| Eldorado High School | Jared Mitchell |
| Elverado High School | Nicole Schenk |
| Farmington High School | Danielle Littrell |
| Fredericktown High School | Brittany Tomlinson |
| Fulton City High School | Susannah Milner |
| Fulton County High School | Andrea Langford |
| Gallatin County High School | Paige Drone |
| Gideon High School | Austin Wade Holiman |
| Goreville High School | Jacalyn Brooke Cochran |
| Greenville R-II High School | Amber Carver |
| Hamilton County High School | Sarah Becker |
| Herrin High School | Michelle Restivo |
| Jackson High School | Jasen Price |
| Johnston City High School | Elliott Mummert |
| Kennett High School | Claire Watson |
| Leopold High School | Janice Jansen |
| Lone Oak High School | Mark C. Capece |
| Malden High School | Luke Lancaster |
| Marion High School | Paul Robert Ashe |
| Marquand-Zion High School | Bradly James Proctor |
| Meadow Heights High School | Rachel Dawn Bequette |
| Mount Vernon Township High School | Lauren Laws |
| Murphysboro High School | Willam Fletcher Bryant |
| Murphysboro High School | Tia Christenson |
| Murphysboro High School | Megan Rose |
| Murray High School | Daniel White |
| Nashville High School | Tara Ryterski |
| Nashville High School | Joshua D. Snead |
| Nashville High School | Patrick Weathers |
| Neelyville High School | Megan Beaird |
| Neelyville High School | Morgan Truelove |
| New Madrid County Central | Elias Taylor Borton |
| New Madrid County Central | Mark Farrenburg |
| New Madrid County Central | Monica Wood |
| North Pemiscot County High School | Macrina Maria Rivera |
| Notre Dame Regional High School | Shannon James |
| Oak Ridge High School | Kia Thomas |
| Oran High School | Mandi Wood |
| Perryville High School | Brittany N. Horneker |
| Pinckneyville High School | Kendra Beth George |
| Pinckneyville High School | Steven Patrick Gibson |
| Pinckneyville High School | R. Erhardt Heisner, II |
| Pope County Community High School | Kyle Volle |
| Portageville High School | DeAnna Kay Deere |
| Portageville High School | Lauren Elizabeth Kellams |
| Portageville High School | Hannah Katherine Rone |
| Puxico High School | Sarah M. Payton |
| Richland High School | Ashley Hicks |
| Richland High School | Sam King |
| Saxony Lutheran High School | Kory Mueller |
| Scott City High School | Daniel Allen Schuenemeyer |
| Sesser-Valier High School | Mariah Adams |
| Sesser-Valier High School | Jennifer Gibson |
| Sesser-Valier High School | Shonda Gulley |
| Shawnee High School | Ellen Spring |
| Sikeston High School | Elizabeth Heeb |
| Southern Reynolds Co. R-II High School | Meagan Morrison |
| St. Vincent High School | Kayli Wibbenmeyer |
| Steeleville High School | Lindsey R. Miller |
| Thomas W. Kelly High School | Stephanie Payne |
| Trico High School | Karen E. Kettner |
| Twin Rivers High School | Robert Rushin |
| Valle Catholic High School | Erin M. Bruns |
| Van Buren High School | Brian N. Heise |
| Webber Township High School | Tyler Ray DeJournett |
| Woodland High School | Rheanna Greer |
| Woodlawn High School | Kristina Arlene Draege |
| Zalma High School | Rebecca Burchett |
| Zeigler-Royalton High School | R. Elliott Vantrease |