Heartland's Best Students - Class of 2005
| High School | Valedictorian |
| Advance High School | Alicia Broshuis |
| Anna-Jonesboro Community High School | Benjamin U. Johnson |
| Arcadia Valley High School | Edwina King |
| Bell City High School | Travis Eakin |
| Bloomfield High School | Dana Marie Tessens |
| Campbell High School | Jessica Nicole Odom |
| Cape Central High School | Kari Ann Bragg |
| Carlisle County High School | Devin Cates |
| Carrier Mills High School | Kendra Threet |
| Carterville High School | Meredith Ellen Simpson |
| Century High School | Robert Andrew Reichert |
| Century High School | Elizabeth Shearer |
| Century High School | Michael Brantley Stricker |
| Charleston High School | Stephanie Renee Beasley |
| Chester High School | Kelly Lankford |
| Christopher High School | Jered DuWayne Montgomery |
| Clarkton High School | Jessica Harrington |
| Clearwater High School | Sara Cummings |
| Clearwater High School | Julie Dawn Morris |
| Clearwater High School | Jessica Polk |
| Coulterville High School | Pamela Plunkett |
| Crab Orchard High School | Nicholas J. Turnage |
| Delta R-5 High School | Sarah Cook |
| Dexter High School | Lynn Marie Plummer |
| Dongola High School | Jessica Miller |
| Dongola High School | Jennifer Miller |
| Dongola High School | Alex Wright |
| Doniphan High School | Nic Gordon |
| Doniphan High School | Daniel Wayne Miller |
| East Carter County High School | Gena Robertson |
| East Prairie High School | Michelle Redman |
| Egyptian High School | Casey Cain |
| Eldorado High School | Jessica Denise Hale |
| Frankfort Community High School | Jessica Hammers |
| Frankfort Community High School | Chris Williams |
| Fredericktown High School | Allie Ammons |
| Fulton City High School | Casey Lyna Kirby |
| Galatia High School | Jennifer Fletcher |
| Goreville High School | Bianca Nicole Puello |
| Greenville High School | Steven C. Fuchs |
| Hamilton County Senior High | Leslie Anne Thierry |
| Hardin County High School | Mackenzie Stunson |
| Hayti High School | Joshua White |
| Hickman County High School | Jaclyn Bailey |
| Hickman County High School | Deane Watson |
| Holcomb High School | Carol Nicole Dye |
| Jackson High School | Rachel Lowes |
| Jackson High School | Lucas McIntosh |
| Kennett High School | Adam Maxwell Parker |
| Leopold High School | Rachel Crader |
| Malden High School | Jordan Beaird |
| Marquand-Zion High School | Maria Weekley |
| Meadow Heights High School | Chasity Wilfong |
| Meridian High School | Kayla Bone |
| Murphysboro High School | Carolyn Cronin |
| Murphysboro High School | Brian Monahan |
| Neelyville High School | Danica K. Babb |
| New Salem Baptist Academy | Mackenzie L. Jones |
| North Pemiscot County High School | Lee Robbins Wilson |
| Notre Dame High School | Brian Matthew McCrate |
| Oak Ridge High School | Hailey Ponder |
| Oran High School | Tori Elizabeth St. Cin |
| Pinckneyville High School | Jonathan Kellerman |
| Richland R-1 High School | Lindsay Manes |
| Richland R-1 High School | Emily Robinson |
| Risco High School | Ashley Smith |
| Saxony Lutheran High School | Deanna Leible |
| Sesser-Valier High School | Mallory Miller |
| Shawnee High School | Julie Hill |
| Sikeston High School | Cullen Edward DeHart |
| Sikeston High School | Katherine E. Jennings |
| South Iron High School | Rebecca Kugel-Rolls |
| Southern Reynolds County R-II High School | CeJay Price |
| Steeleville High School | Matthew Guebert |
| St. Vincent High School | Danny Rellergert |
| Thomas W. Kelly High School | William Beggs |
| Trico High School | |
| Trico High School | Jeanna Dawn Ohlau |
| Twin Rivers High School | Mason Redmon |
| Twin Rivers High School | Jared Stockton |
| Valle Catholic High School | Mitchell Kenyon Davis |
| Van Buren High School | Jerri Diann Fowler |
| Vienna High School | Kaylyn J. Adams |
| Vienna High School | Katie Ochs |
| Waltonville High School | Randa Marie Arnold |
| Webber Township High School | Ashley Riley |
| Woodland High School | Sara Jean Brown |
| Woodlawn High School | Shaun Willis |
| Zalma High School | Dena Mayberry |