It's easy to get your cholesterol checked. Leoni says everyone should have a base screening when they hit adulthood. If you don't have any problems you can have it done every three to five years after that screening. If you have a family history of heart disease you should start getting your cholesterol checked in your teens, and keep a close eye on it every year. "We don't want them to wait too long, especially when you have high cholesterol coupled with a sedentary lifestyle, if you're overweight, smoke, or if you're diabetic. If you put that together you have a real time bomb for heart disease," she says.