Mississippi County Coroner Terry Parker says Billy R. Hatton, 48, of East Prairie was killed in the crash.
It happened around noon on County Road 527 just south of East Prairie.
Hatton's 2008 Polaris ATV ran off the the right side of the road and struck a tree. The ATV overturned and threw Hatton from the vehicle, according to the Missouri State Highway Patrol.
Parker says Hatton was taken to a Sikeston hospital where he was pronounced dead just before 1:30 p.m.
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